The specialist agency appointed by the canton must be informed immediately in the event that, when handling organisms in contained systems:
organisms that should have been prevented from escaping into the environment under Article 12 paragraph 1 have done so;
there was a genuine risk of organisms being released into the environment in the course of activities in Classes 3 and 4; or
there is a strong suspicion of improper use.
The cantons shall inform the competent federal office of any reported incidents.